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Abstract #4258

Tissue Volume Fraction as a biomarker of genetically-determined disease burden in Huntington's disease

Jessica Steventon 1 , Rebecca Trueman 2 , Anne E Rosser 3 , and Derek K Jones 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom, 2 University of Nottingham, England, United Kingdom, 3 School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom

Widespread atrophy occurs in Huntingtons disease (HD) and cerebrospinal fluid (CSF) fills the remaining space, which can lead to an increased CSF-based partial volume artefact in diffusion MRI studies. In this work, we use the tissue volume fraction (TVF) which is a metric of the signal from tissue after eliminating the partial volume component. We compared the relative sensitivity of TVF and diffusion tensor indices in predicting disease burden in HD and find that TVF is more sensitive to a genetic marker of disease severity and to reported functional capacity, and should be adopted as a microstructural metric.

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