Abstract #4258
Tissue Volume Fraction as a biomarker of genetically-determined disease burden in Huntington's disease
Jessica Steventon 1 , Rebecca Trueman 2 , Anne E Rosser 3 , and Derek K Jones 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, Wales, United Kingdom,
2
University
of Nottingham, England, United Kingdom,
3
School
of Biosciences, Cardiff University, Cardiff, Wales,
United Kingdom
Widespread atrophy occurs in Huntingtons disease (HD)
and cerebrospinal fluid (CSF) fills the remaining space,
which can lead to an increased CSF-based partial volume
artefact in diffusion MRI studies. In this work, we use
the tissue volume fraction (TVF) which is a metric of
the signal from tissue after eliminating the partial
volume component. We compared the relative sensitivity
of TVF and diffusion tensor indices in predicting
disease burden in HD and find that TVF is more sensitive
to a genetic marker of disease severity and to reported
functional capacity, and should be adopted as a
microstructural metric.
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