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Abstract #4259

Altered Topological Properties of Functional Connectome in Early-Stage PD Revealed by Graph Theoretical Analysis

Xueling Suo 1 , Du Lei 1 , Fuqin Chen 1 , Lei Li 1 , Nannan Li 2 , Lan Cheng 2 , Rong Peng 2 , and Qiyong Gong 1

1 Huaxi MR Research Center (HMRRC), Department of Radiolody, West China Hospital, Chengdu, Sichuan, China, 2 Department of Neurology, West China Hospital, Chengdu, Sichuan, China

Parkinson's disease (PD) is a progressive neurodegenerative disease. Previous resting-state fMRI studies of PD have primarily focused on ROI methods. Recently there have been emerging studies employing graph theoretical approaches to investigate the structural and functional brain connectome of PD patients. However, little is known as to the topological characteristics of functional connectome of early-stage PD. Our study aimed to investigate topological Properties of the functional connectome in early-stage PD patients with mild cognitive impairment by graph theoretical analysis

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