Abstract #4259
Altered Topological Properties of Functional Connectome in Early-Stage PD Revealed by Graph Theoretical Analysis
Xueling Suo 1 , Du Lei 1 , Fuqin Chen 1 , Lei Li 1 , Nannan Li 2 , Lan Cheng 2 , Rong Peng 2 , and Qiyong Gong 1
1
Huaxi MR Research Center (HMRRC), Department
of Radiolody, West China Hospital, Chengdu, Sichuan,
China,
2
Department
of Neurology, West China Hospital, Chengdu, Sichuan,
China
Parkinson's disease (PD) is a progressive
neurodegenerative disease. Previous resting-state fMRI
studies of PD have primarily focused on ROI methods.
Recently there have been emerging studies employing
graph theoretical approaches to investigate the
structural and functional brain connectome of PD
patients. However, little is known as to the topological
characteristics of functional connectome of early-stage
PD. Our study aimed to investigate topological
Properties of the functional connectome in early-stage
PD patients with mild cognitive impairment by graph
theoretical analysis
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