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Abstract #4260

MRI Guided Magnetic Nanoparticle Based Drug Delivery for Neurodegenerative Diseases: Preliminary In-vivo and In-vitro Study

Yujuan Zhao 1 , Noah Snyder 1 , Tiejun Zhao 2 , Liza Bruk 1 , James Eles 1 , Xia Li 1 , X. Tracy Cui 1 , and Tamer S. Ibrahim 1

1 University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Siemens Medical Solutions USA, Pittsburgh, Pennsylvania, United States

Neurodegenerative diseases are generally not well-understood with no effective drugs available to treat and prevent these diseases. A potent antioxidant compound could be incorporated in magnetic nanoparticles (MNPs) and delivered into central nervous systems (CNS) tissue for lowering oxidative stress related to numerous neurodegenerative diseases. In this study, the feasibility of using MRI fields to trigger the drug loaded MNPs is investigated. In-vitro and in-vivo results are provided and In-vivo drug release from silica magnetic nanoparticles via MRI stimulation was demonstrated by observing fluorescein release from silica magnetic nanoparticles injected into the brain of rodents.

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