Abstract #4260
MRI Guided Magnetic Nanoparticle Based Drug Delivery for Neurodegenerative Diseases: Preliminary In-vivo and In-vitro Study
Yujuan Zhao 1 , Noah Snyder 1 , Tiejun Zhao 2 , Liza Bruk 1 , James Eles 1 , Xia Li 1 , X. Tracy Cui 1 , and Tamer S. Ibrahim 1
1
University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
2
Siemens
Medical Solutions USA, Pittsburgh, Pennsylvania, United
States
Neurodegenerative diseases are generally not
well-understood with no effective drugs available to
treat and prevent these diseases. A potent antioxidant
compound could be incorporated in magnetic nanoparticles
(MNPs) and delivered into central nervous systems (CNS)
tissue for lowering oxidative stress related to numerous
neurodegenerative diseases. In this study, the
feasibility of using MRI fields to trigger the drug
loaded MNPs is investigated. In-vitro and in-vivo
results are provided and In-vivo drug release from
silica magnetic nanoparticles via MRI stimulation was
demonstrated by observing fluorescein release from
silica magnetic nanoparticles injected into the brain of
rodents.
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