Aberrant brain network connectivity assessed using graph theory in paroxysmal kinesigenic dyskinesia
Lei Li 1 , Du Lei 2 , Xueling Suo 2 , Xinyu Hu 2 , Jiechuan Ren 3 , Xiaoqi Huang 2 , and Qiyong Gong 2
Huaxi MR Research Center (HMRRC), Department
of Radiology, West China Hospital of Sichuan University,
Chengdu, Sichuan, China,
MR Research Center (HMRRC), Department of Radiology,
West China Hospital of Sichuan University, Sichuan,
of Neurology, West China Hospital of Sichuan University,
Paroxysmal kinesigenic dyskinesia (PKD) is a rare
neurological disorder characterized by sudden attack of
choreoathetosis or dystonia. The basal
ganglia-thalamo-cortical motor circuits is proposed as
the pathophysiological basis of the PKD disease. The
purpose of this study is to detect the topological
organization of whole-brain networks in PKD using graph
theoretical approaches. The result showed PKD patients
exhibited a much more active global and local
connectivity characterized by higher local
specialization and global integration than controls.
Especially, the patients exhibited enhanced nodal
centralities in the basal ganglia, supporting the idea
that PKD is sequence of basal ganglia dysfunction.
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