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Abstract #4261

Aberrant brain network connectivity assessed using graph theory in paroxysmal kinesigenic dyskinesia

Lei Li 1 , Du Lei 2 , Xueling Suo 2 , Xinyu Hu 2 , Jiechuan Ren 3 , Xiaoqi Huang 2 , and Qiyong Gong 2

1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Sichuan, China, 3 Department of Neurology, West China Hospital of Sichuan University, Sichuan, China

Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurological disorder characterized by sudden attack of choreoathetosis or dystonia. The basal ganglia-thalamo-cortical motor circuits is proposed as the pathophysiological basis of the PKD disease. The purpose of this study is to detect the topological organization of whole-brain networks in PKD using graph theoretical approaches. The result showed PKD patients exhibited a much more active global and local connectivity characterized by higher local specialization and global integration than controls. Especially, the patients exhibited enhanced nodal centralities in the basal ganglia, supporting the idea that PKD is sequence of basal ganglia dysfunction.

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