Abstract #4262
QSM of Substantia Nigra and Improved Characterization of Substantia Nigra
Jason Langley 1 , Daniel E Huddleston 2 , Nishant Zachariah 3 , Xiangchuan Chen 1 , and Xiaoping Hu 1
1
Wallace H. Coulter Department of Biomedical
Engineering, Emory University and Georgia Institute of
Technology, Atlanta, GA, United States,
2
Center
for Health Research, Southeast, Kaiser Permanente,
Atlanta, GA, United States,
3
Department
of Electrical and Computer Engineering, Georgia
Institute of Technology, Atlanta, GA, United States
Degeneration of the substantia nigra (SN) is a hallmark
of many neurodegenerative disorders including
Parkinsons disease and visualization and volumetric
quantification of the SN would be beneficial to early
detection of PD. Magnetization transfer contrast (MTC)
imaging is sensitive to neuromelanin-containing
structures in the brain quantitative susceptibility
mapping (QSM) is sensitive to iron. This abstract
compares the segmentation results and signal
characteristics of the SN from MTC images and QSM maps.
We found neuromelanin and iron sensitive regions are
spatially incongruent and have different signal
characteristics.
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