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Abstract #4262

QSM of Substantia Nigra and Improved Characterization of Substantia Nigra

Jason Langley 1 , Daniel E Huddleston 2 , Nishant Zachariah 3 , Xiangchuan Chen 1 , and Xiaoping Hu 1

1 Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States, 2 Center for Health Research, Southeast, Kaiser Permanente, Atlanta, GA, United States, 3 Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States

Degeneration of the substantia nigra (SN) is a hallmark of many neurodegenerative disorders including Parkinsons disease and visualization and volumetric quantification of the SN would be beneficial to early detection of PD. Magnetization transfer contrast (MTC) imaging is sensitive to neuromelanin-containing structures in the brain quantitative susceptibility mapping (QSM) is sensitive to iron. This abstract compares the segmentation results and signal characteristics of the SN from MTC images and QSM maps. We found neuromelanin and iron sensitive regions are spatially incongruent and have different signal characteristics.

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