Abstract #4268
Alterations of Cerebral Cortical Thickness in the Sensory and Pain Systems in Restless Legs Syndrome
Byeong-Yeul Lee 1 , James R. Connor 2 , Wei Chen 1 , and Qing X. Yang 2,3
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota,
Minneapolis, MN, United States,
2
Department
of Neurosurgery, The Pennsylvania State University
College of Medicine, Hershey, PA, United States,
3
Center
for NMR Research, Department of Radiology, The
Pennsylvania State University College of Medicine,
Hershey, PA, United States
Restless legs syndrome (RLS) is a neurological disorder
characterized by extremely uncomfortable senstations in
the limbs. Due to the explicit presence of the sensory
and pain symptoms in patients with RLS, we investigated
the cortical thickness in the sensory-motor and the
central pain system using advanced surface
classification method. Compared to controls, both
vertex-wise and ROI-based analysis revealed that RLS
exhibits a significantly reduced cortical thickness in
the postcentral cortex and increased cortical thickness
in the cingulate cortex bilaterally. These findings of
involvement of the sensory and the pain system in RLS
gain new insights for better understanding of the
pathophysiology underlying RLS, and the abnormal
cortical thickness in these brain regions could provide
a useful surrogate marker for studying RLS and
diagnosis.
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