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Abstract #4269

Spatiotemporal Changes in Ocular Morphology and White Matter Integrity in a Transgenic Mouse Model of Chronic Glaucoma

Xiao-Ling Yang 1,2 , Leon C. Ho 1,3 , Yolandi van der Merwe 1,4 , Ian P. Conner 2,4 , Seong-Gi Kim 1,5 , Gadi Wollstein 2 , Joel S. Schuman 2,4 , and Kevin C. Chan 1,2

1 NeuroImaging Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 3 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China, 4 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 5 Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea

This study determined spatiotemporally the progression of intraocular pressure, ocular morphology and microstructural integrity of the visual pathways in transgenic DBA/2J mice and age-matched C57BL/6J mice using high-resolution anatomical MRI and diffusion tensor MRI at 9.4 Tesla in order to better understand the etiology and pathophysiological events during glaucoma progression . Our data showed that the ocular dimensions and microstructures of visual pathway in D2 began to change at the onset of IOP increase at 8-9 months old, which progressed further at 12 months old, resulting in significant deterioration in visuomotor function compared to B6 mice of the same age. In addition, caution should be taken when using C57BL/6J mice as an age-matched negative given the slight but significant increase in IOP and compromised microstructural integrity at older ages.

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