Abstract #4269
Spatiotemporal Changes in Ocular Morphology and White Matter Integrity in a Transgenic Mouse Model of Chronic Glaucoma
Xiao-Ling Yang 1,2 , Leon C. Ho 1,3 , Yolandi van der Merwe 1,4 , Ian P. Conner 2,4 , Seong-Gi Kim 1,5 , Gadi Wollstein 2 , Joel S. Schuman 2,4 , and Kevin C. Chan 1,2
1
NeuroImaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Department
of Ophthalmology, School of Medicine, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
3
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
4
Department
of Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, Pennsylvania,
United States,
5
Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
This study determined spatiotemporally the progression
of intraocular pressure, ocular morphology and
microstructural integrity of the visual pathways in
transgenic DBA/2J mice and age-matched C57BL/6J mice
using high-resolution anatomical MRI and diffusion
tensor MRI at 9.4 Tesla in order to better understand
the etiology and pathophysiological events during
glaucoma progression . Our data showed that the ocular
dimensions and microstructures of visual pathway in D2
began to change at the onset of IOP increase at 8-9
months old, which progressed further at 12 months old,
resulting in significant deterioration in visuomotor
function compared to B6 mice of the same age. In
addition, caution should be taken when using C57BL/6J
mice as an age-matched negative given the slight but
significant increase in IOP and compromised
microstructural integrity at older ages.
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