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Abstract #4274

Insight into Neuromelanin-MRI Z-spectrum contrast of the Substantia Nigra

Paula Trujillo 1,2 , Paul Summers 1 , Luca Mainardi 2 , Sergio Cerutti 2 , Seth A Smith 3,4 , Alex K Smith 3,4 , and Antonella Costa 1

1 Department of Neuroradiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, MI, Italy, 2 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, MI, Italy, 3 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 4 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

In Neuromelanin-sensitive MRI, magnetization transfer (MT) prepulses improve the observable contrast of neuromelanin (NM) containing structures (i.e. Substantia Nigra (SN) and Locus Coeruleus (LC)) relative to surrounding tissues. The purpose of the study was to assess the effect of the MT pulses by examining the z-spectra of the SN and its surrounding tissues in turbo-spin echo (TSE) and gradient echo images. Maximal MT effect was seen for MT pulses at an offset of 835 and 1525 Hz for TSE and gradient echo sequences respectively.

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