Abstract #4274
Insight into Neuromelanin-MRI Z-spectrum contrast of the Substantia Nigra
Paula Trujillo 1,2 , Paul Summers 1 , Luca Mainardi 2 , Sergio Cerutti 2 , Seth A Smith 3,4 , Alex K Smith 3,4 , and Antonella Costa 1
1
Department of Neuroradiology, Fondazione
IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan,
MI, Italy,
2
Department
of Electronics, Information and Bioengineering,
Politecnico di Milano, Milan, MI, Italy,
3
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
4
Department
of Biomedical Engineering, Vanderbilt University,
Nashville, TN, United States
In Neuromelanin-sensitive MRI, magnetization transfer
(MT) prepulses improve the observable contrast of
neuromelanin (NM) containing structures (i.e. Substantia
Nigra (SN) and Locus Coeruleus (LC)) relative to
surrounding tissues. The purpose of the study was to
assess the effect of the MT pulses by examining the
z-spectra of the SN and its surrounding tissues in
turbo-spin echo (TSE) and gradient echo images. Maximal
MT effect was seen for MT pulses at an offset of 835 and
1525 Hz for TSE and gradient echo sequences
respectively.
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