Abstract #4275
Quantitative susceptibility mapping as a potential biomarker in Parkinson's disease: a clinical application study
Sung-han Lin 1 , Chin-Song Lu 2 , Yi-Hsin Weng 2 , Yao-Liang Chen 3 , Yi-Ming Wu 3 , and Jiun-Jie Wang 1
1
Medical Imaging and Radiological Science,
Chang Gung University, Taoyuan County, Taiwan, Taiwan,
2
Department
of Neurology, Chang Gung Memorial Hospital and College
of Medicine, Chang Gung University, Taoyuan, Taiwan,
3
Department
of Radiology and Intervention, Chang Gung Memorial
Hospital, Taoyuan, Taiwan
The Parkinsons disease (PD) has been associated with
iron deposition in the basal ganglia and striatum.The
Quantitative Susceptibility Mapping (QSM) was applied
for measurement of the susceptibility differences
between PD patients and normal controls. We investigated
the PD affected regions including the caudate nucleus,
the red nucleus, the globus pallidus, the putamen, and
the substantia nigra. We found that the regions with
significant increased susceptibility were consistent
with the PD pathology and suggested that the feasibility
of QSM as a sensitive method for the measurement of the
severity of the pathological changes underlying PD
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