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Abstract #4275

Quantitative susceptibility mapping as a potential biomarker in Parkinson's disease: a clinical application study

Sung-han Lin 1 , Chin-Song Lu 2 , Yi-Hsin Weng 2 , Yao-Liang Chen 3 , Yi-Ming Wu 3 , and Jiun-Jie Wang 1

1 Medical Imaging and Radiological Science, Chang Gung University, Taoyuan County, Taiwan, Taiwan, 2 Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan, 3 Department of Radiology and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

The Parkinsons disease (PD) has been associated with iron deposition in the basal ganglia and striatum.The Quantitative Susceptibility Mapping (QSM) was applied for measurement of the susceptibility differences between PD patients and normal controls. We investigated the PD affected regions including the caudate nucleus, the red nucleus, the globus pallidus, the putamen, and the substantia nigra. We found that the regions with significant increased susceptibility were consistent with the PD pathology and suggested that the feasibility of QSM as a sensitive method for the measurement of the severity of the pathological changes underlying PD

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