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Abstract #4282

Longitudinal Diffusion Tensor Imaging of the Rat Brain after Hexachlorophene Exposure

Jaivijay Ramu 1 , Tetyana Konak 1 , Merle G Paule 1 , Joseph Hanig 2 , and Serguei Liachenko 1

1 Neurotoxicology, NCTR / FDA, Jefferson, AR, United States, 2 OTR, CDER / FDA, White Oak, MD, United States

Diffusion Tensor Imaging was used to characterize the life cycle of the hexachlorophene (HC) induced neurotoxicity in the rat brain. Axial and radial diffusivity as well as ADC has dramatically increased after the start of HC treatment, reaching its peak at day 6 and reversing back to normal at day 20, while FA did not change significantly. These changes suggest about transient changes in myelinated brain tissue of the rat, consistent with edema.

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