Abstract #4282
Longitudinal Diffusion Tensor Imaging of the Rat Brain after Hexachlorophene Exposure
Jaivijay Ramu 1 , Tetyana Konak 1 , Merle G Paule 1 , Joseph Hanig 2 , and Serguei Liachenko 1
1
Neurotoxicology, NCTR / FDA, Jefferson, AR,
United States,
2
OTR,
CDER / FDA, White Oak, MD, United States
Diffusion Tensor Imaging was used to characterize the
life cycle of the hexachlorophene (HC) induced
neurotoxicity in the rat brain. Axial and radial
diffusivity as well as ADC has dramatically increased
after the start of HC treatment, reaching its peak at
day 6 and reversing back to normal at day 20, while FA
did not change significantly. These changes suggest
about transient changes in myelinated brain tissue of
the rat, consistent with edema.
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