Abstract #4281
Quantitative Susceptibility Mapping of the motor cortex in ALS and PLS patients: A Biomarker for Upper Motor Neuron Dysfunction
Gerd Melkus 1,2 , Santanu Chakraborty 1,2 , and Pierre Bourque 3
1
Department of Medical Imaging, The Ottawa
Hospital, Ottawa, ON, Canada,
2
Department
of Radiology, University of Ottawa, Ottawa, ON, Canada,
3
Department
of Neurology, University of Ottawa, Ottawa, ON, Canada
There is no definite technique for demonstrating UMN
involvement in ALS/PLS and UMN findings on clinical
examination may not be evident until late in the disease
course. T2 hypointensity in the motor cortex in ALS has
been described before and can be assessed better due to
increased resolution of SWI. QSM processing and analysis
of the motor cortex and control area enables
quantification of these signal changes. In our series
there is a significant correlation between QSM values
and presence of UMN signs (spasticity). However, larger
prospective studies will be needed to determine
diagnostic and prognostic value of this sign.
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