Abstract #4280
A Tract Based Spatial Statistic study of Fractional Anisotropy alterations caused by Simian Immunodeficiency Virus infection
Zhenchao Tang 1 , Zhenyu Liu 2 , Jiaojiao Liu 3 , Hongjun Li 3 , Enqing Dong 1 , and Jie Tian 2
1
School of Mechanical, Electrical &
Information Engineering, Shandong University, Weihai,
Shandong Province, China,
2
Institute
of Automation, Chinese Academy of Sciences, Beijing,
China,
3
Beijing
YouAn Hospital, Capital Medical University, Beijing,
China
Simian immunodeficiency virus (SIV) infection causes
Fractional Anisotropy (FA) alterations, which represent
white matter integrity degeneration. In our longitudinal
study, we used Tract Based Spatial Statistic (TBSS) to
access white matter integrity degeneration with the
advance of disease. We find that SIV impairs macaque
white matter integrity in the inferior temporal regions
selectively, and may cause damage to the ventral visual
pathway. The results are consistent with previous
studies on HIV affected patients. We also find that
Lower FA values were correlated with higher CD4+/CD8+
ratio. Our MRI findings indicate that FA may be a
potential marker for monitoring the disease progression.
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