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Abstract #4280

A Tract Based Spatial Statistic study of Fractional Anisotropy alterations caused by Simian Immunodeficiency Virus infection

Zhenchao Tang 1 , Zhenyu Liu 2 , Jiaojiao Liu 3 , Hongjun Li 3 , Enqing Dong 1 , and Jie Tian 2

1 School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, Shandong Province, China, 2 Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3 Beijing YouAn Hospital, Capital Medical University, Beijing, China

Simian immunodeficiency virus (SIV) infection causes Fractional Anisotropy (FA) alterations, which represent white matter integrity degeneration. In our longitudinal study, we used Tract Based Spatial Statistic (TBSS) to access white matter integrity degeneration with the advance of disease. We find that SIV impairs macaque white matter integrity in the inferior temporal regions selectively, and may cause damage to the ventral visual pathway. The results are consistent with previous studies on HIV affected patients. We also find that Lower FA values were correlated with higher CD4+/CD8+ ratio. Our MRI findings indicate that FA may be a potential marker for monitoring the disease progression.

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