Abstract #4279
Altered Spontaneous Brain Activity in Type 2 Diabetes Related Cognitive Dysfunction: a Resting-State Functional MRI Study
Ying Xiong 1 , Zhipeng Xu 2 , Qiang Zhang 3 , Shiqi Yang 1 , Shun Zhang 1 , and Wenzhen Zhu 1
1
Department of Radiology, Tongji Hospital,
Tongji Medical College, Huazhong University of Science
and Technology, Wuhan, Hubei, China,
2
Pathophysiology
Department, Tongji Medical College, Huazhong University
of Science and Technology, Wuhan, Hubei, China,
3
Neurology
department, Tongji Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan,
Hubei, China
This study aims to investigate the possible alterations
in spontaneous neural activity through resting-state
functional MRI (rs-fMRI) in type 2 diabetes mellitus
(T2DM) related cognitive impairment. Thirty-four T2DM
patients were divided into two groups based on their
cognition status. The intrinsic and spontaneous neural
activity, represented by the regional homogeneity (ReHo),
was detected to decrease in right temporal regions and
to increase in bilateral frontal regions. Weaker
connectivities of multiple brain regions were also
revealed in the cognitive impairment group. These
multi-functional brain disorders revealed by rs-fMRI may
help to discover the susceptible regions to T2DM induced
cognitive dysfunction.
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