Abstract #4278
Assessing Iron Load in Deep Grey Matter Brain Nuclei of Parkinson's Disease with L2-Regularized Quantitative Susceptibility Mapping
Darrell Ting Hung Li 1 , Edward Sai Kam Hui 1 , Queenie Chan 2 , Siew-eng Chua 3 , Grainne McAlonan 3,4 , Shu Leong Ho 5 , and Henry Ka Fung Mak 1
1
Department of Diagnostic Radiology, The
University of Hong Kong, Hong Kong, Hong Kong,
2
Philips
Healthcare, Hong Kong, China,
3
Department
of Psychiatry, Queen Mary Hospital, The University of
Hong Kong, Hong Kong,
4
Department
of Forensic and Neurodevelopmental Science, Institute of
Psychiatry, Kings College London, London, United
Kingdom,
5
Department
of Medicine, The University of Hong Kong, Hong Kong
Degeneration of dopaminergic neuron is one of the major
clinical characteristics of Parkinsons disease (PD).
Abnormal iron deposition in the mid-brain nuclei was
postulated to be the cause of neurodegeneration. In this
study, we employed quantitative susceptibility mapping
(QSM) as a tool to examine iron content of different
brain nuclei. Iron concentrations in terms of magnetic
susceptibility of the 6 brain nuclei were presented. ROI
analysis revealed high iron concentration in substantia
nigra of PD patients which confirmed the clinical
findings. This study also demonstrated QSM as a
potential tool for evaluation of
in
vivo
iron
metabolism in neurodegenerative disease.
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