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Abstract #4278

Assessing Iron Load in Deep Grey Matter Brain Nuclei of Parkinson's Disease with L2-Regularized Quantitative Susceptibility Mapping

Darrell Ting Hung Li 1 , Edward Sai Kam Hui 1 , Queenie Chan 2 , Siew-eng Chua 3 , Grainne McAlonan 3,4 , Shu Leong Ho 5 , and Henry Ka Fung Mak 1

1 Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2 Philips Healthcare, Hong Kong, China, 3 Department of Psychiatry, Queen Mary Hospital, The University of Hong Kong, Hong Kong, 4 Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Kings College London, London, United Kingdom, 5 Department of Medicine, The University of Hong Kong, Hong Kong

Degeneration of dopaminergic neuron is one of the major clinical characteristics of Parkinsons disease (PD). Abnormal iron deposition in the mid-brain nuclei was postulated to be the cause of neurodegeneration. In this study, we employed quantitative susceptibility mapping (QSM) as a tool to examine iron content of different brain nuclei. Iron concentrations in terms of magnetic susceptibility of the 6 brain nuclei were presented. ROI analysis revealed high iron concentration in substantia nigra of PD patients which confirmed the clinical findings. This study also demonstrated QSM as a potential tool for evaluation of in vivo iron metabolism in neurodegenerative disease.

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