Abstract #4277
Altered striatal functional connectivity in Parkinson's disease patients with impulse control disorder
Yi-Ming Wu 1 , Chin-Song Lu 2 , Yi-Hsin Weng 2 , Yao-Liang Chen 1 , Sung-han Lin 3 , and Jiun-Jie Wang 3
1
Department of Radiology and Intervention,
Chang Gung Memorial Hospital, Taoyuan, Taiwan,
2
Department
of Neurology, Chang Gung Memorial Hospital and College
of Medicine, Chang Gung University, Taoyuan, Taiwan,
3
Medical
Imaging and Radiological Science, Chang Gung University,
Taoyuan, Taiwan
To evaluate the capability of resting state functional
MRI in indentifying the disease-specific changes in
functional brain networks from PD patients with or
without impulse control disorders (ICD).PD patients
showed significantly enhanced striatal functional
connectivity with sensori-motor cortex.Compared with
healthy subjects and PD patients without ICD, PD
patients with ICD also showed significantly increased
striatal connectivity with the ACC and prefrontal
cortex, which are involved in execution and reward
system.This study shows that mapping striatal functional
connectivity is feasible and may aid in understanding
the pathophysiology of PD and ICD.
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