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Abstract #4277

Altered striatal functional connectivity in Parkinson's disease patients with impulse control disorder

Yi-Ming Wu 1 , Chin-Song Lu 2 , Yi-Hsin Weng 2 , Yao-Liang Chen 1 , Sung-han Lin 3 , and Jiun-Jie Wang 3

1 Department of Radiology and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2 Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan, 3 Medical Imaging and Radiological Science, Chang Gung University, Taoyuan, Taiwan

To evaluate the capability of resting state functional MRI in indentifying the disease-specific changes in functional brain networks from PD patients with or without impulse control disorders (ICD).PD patients showed significantly enhanced striatal functional connectivity with sensori-motor cortex.Compared with healthy subjects and PD patients without ICD, PD patients with ICD also showed significantly increased striatal connectivity with the ACC and prefrontal cortex, which are involved in execution and reward system.This study shows that mapping striatal functional connectivity is feasible and may aid in understanding the pathophysiology of PD and ICD.

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