Abstract #4284
Transverse Relaxation and Volumetric Neural Changes in the H67D HFE Mouse Model and Cognitively Normal Healthy H63D-HFE Human Genotype Carriers
Douglas G Peters 1,2 , Carson J Purnell 1 , Jian-Li Wang 3 , Paul J Eslinger 4 , Megha Vasavada 3 , Fatima Ali-Rahmani 1 , Qing X Yang 3 , James R Connor 1 , and Mark David Meadowcroft 1,3
1
Neurosurgery, The Pennsylvania State
University - College of Medicine, Hershey, Pennsylvania,
United States,
2
Neural
and Behavioral Sciences, The Pennsylvania State
University - College of Medicine, Hershey, Pennsylvania,
United States,
3
Radiology,
The Pennsylvania State University - College of Medicine,
Hershey, Pennsylvania, United States,
4
Neurology,
The Pennsylvania State University - College of Medicine,
Hershey, Pennsylvania, United States
A voxel-based statistical parametric analysis of R
2
transverse
relaxation in cognitively normal H63D-HFE human and H67D
knock-in mice compared to control patients and mice was
accomplished. Widespread decreases in relaxation were
found in white association fibers throughout the brain
of H63D patients and in white matter tracks of the H67D
mice. The R
2
changes
observed in both the human-H63D and mouse-H67D data
suggest that the sequential process of myelinogenesis is
refashioned, resulting in modified myelin membrane
proton compartmentalization in patients with HFE
mutations.
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