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Abstract #4285

Lateralization of Temporal Lobe Epilepsy using a Combinational Model of Electroencephalographic and Imaging

Fariborz Mahmoudi 1,2 , Mohammad-Reza Nazem-Zadeh 1 , Jason M. Schwalb 3 , Ellen L. Air 3 , Hassan Bagher-Ebadian 1 , Manpreet Kaur 3 , Rushna Ali 3 , Saeed Shokri 1 , Kost V. Elisevich 4 , and Hamid Soltanian-Zadeh 1,5

1 Departments of Radiology, Research Administration, Henry Ford Health System, Detroit, Michigan, United States, 2 Computer and It Engineering Faculty, Islamic Azad University, Qazvin Branch, Qazvin, Qazvin, Iran, 3 Departments of Neurosurgery, Henry Ford Health System, Detroit, Michigan, United States, 4 Department of Clinical Neurosciences, Spectrum Health System, Grand Rapids, Michigan, United States, 5 CIPCE, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran

Mesial temporal lobe epilepsy (mTLE) is the most common type of refractory focal epilepsy. Concordant electroencephalographic, neuropsychological and Magnetic Resonance Imaging (MRI) findings often lateralize the epileptogenic side permitting surgical resection of the mesial temporal structures, without further investigation. In cases of unclear lateralization, implantation of intracranial electrodes for long term monitoring (Phase II) is needed to localize the epileptogenic zone. Unfortunately, Phase II monitoring may lead to infection, intracranial hemorrhage, and elevated intracranial pressure. In this study, we have developed, a combinational model based on imaging and other diagnostic procedures to try to reduce the need for Phase II monitoring. Briefly the purpose of this study is, developing a model that would not only enhance patient safety, but also would reduce economic burden.

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