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Abstract #4286

Detecting Alterations in Caudal Portion of Substantia Nigra in Parkinsons Disease

Xiangchuan Chen 1 , Daniel Huddleston 1,2 , Jason Langley 1 , and Xiaoping Hu 1

1 Emory University, Atlanta, Georgia, United States, 2 Kaiser Permanente Center for Health Research Southeast, Atlanta, Georgia, United States

Alterations in the caudal portion of substantia nigra (SN) in Parkinsons disease (PD) were investigated through magnetic resonance imaging (MRI) of a PD and a control groups. By measuring the volumes of SN in different slice locations, we found that the PD patients had smaller SN than the controls in the caudal portion of SN. The distance between the centers of mass of the left and right SNs was also shorter in the PD than in the controls in the same locations. These results are consistent with the findings of histological studies on post mortem brains.

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