Abstract #4286
Detecting Alterations in Caudal Portion of Substantia Nigra in Parkinsons Disease
Xiangchuan Chen 1 , Daniel Huddleston 1,2 , Jason Langley 1 , and Xiaoping Hu 1
1
Emory University, Atlanta, Georgia, United
States,
2
Kaiser
Permanente Center for Health Research Southeast,
Atlanta, Georgia, United States
Alterations in the caudal portion of substantia nigra
(SN) in Parkinsons disease (PD) were investigated
through magnetic resonance imaging (MRI) of a PD and a
control groups. By measuring the volumes of SN in
different slice locations, we found that the PD patients
had smaller SN than the controls in the caudal portion
of SN. The distance between the centers of mass of the
left and right SNs was also shorter in the PD than in
the controls in the same locations. These results are
consistent with the findings of histological studies on
post mortem brains.
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