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Abstract #4287

Eigenvector centrality of resting-state fMRI in the brainstem: A potential marker for Parkinson's disease pathology

tefan Holiga 1,2 , Robert Jech 3 , Karsten Mueller 1 , Duan Urgok 4 , Matthias L. Schroeter 1,2 , and Harald E. Mller 1

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Clinic for Cognitive Neurology & Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, 3 Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Czech Republic, 4 Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, Prague, Czech Republic

Early stages of Parkinsons disease (PD) are associated with the pathology occurring in the lower brainstem and gradually progressing towards the neocortex. PD is already in later stages when the pathology targets the substantia nigra and motor symptoms become apparent. Here, we found a correspondence between the ascending gradient of PD-pathology and functional connectivity patterns of the resting-state-(rs)-fMRI in the brainstem. Rs-fMRI of the brainstem should be therefore considered as a potential non-invasive marker of the diseases early phases. These findings invigorate the overlooked brainstem perspective in the understanding of PD and support the current trend towards its early diagnosis.

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