Abstract #4287
Eigenvector centrality of resting-state fMRI in the brainstem: A potential marker for Parkinson's disease pathology
tefan Holiga 1,2 , Robert Jech 3 , Karsten Mueller 1 , Duan Urgok 4 , Matthias L. Schroeter 1,2 , and Harald E. Mller 1
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
2
Clinic
for Cognitive Neurology & Leipzig Research Center for
Civilization Diseases, University of Leipzig, Leipzig,
Germany,
3
Department
of Neurology and Center of Clinical Neuroscience, First
Faculty of Medicine, Charles University in Prague, Czech
Republic,
4
Department
of Radiation and Stereotactic Neurosurgery, Na Homolce
Hospital, Prague, Czech Republic
Early stages of Parkinsons disease (PD) are associated
with the pathology occurring in the lower brainstem and
gradually progressing towards the neocortex. PD is
already in later stages when the pathology targets the
substantia nigra and motor symptoms become apparent.
Here, we found a correspondence between the ascending
gradient of PD-pathology and functional connectivity
patterns of the resting-state-(rs)-fMRI in the
brainstem. Rs-fMRI of the brainstem should be therefore
considered as a potential non-invasive marker of the
diseases early phases. These findings invigorate the
overlooked brainstem perspective in the understanding of
PD and support the current trend towards its early
diagnosis.
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