Abstract #4288
An MRI-based method to quantify apoptosis in vivo
Chenchen Liu 1 , Nuri B Farber 2 , Joel R Garbow 3 , and Joseph JH Ackerman 4
1
Chemistry, Washington University in
St.Louis, St. Louis, MO, United States,
2
Psychiatry,
Washington University in St.Louis, St. Louis, MO, United
States,
3
Radiology, Washington University in
St.Louis, St. Louis, MO, United States,
4
Chemistry
and Radiology, Washington University in St.Louis, St.
Louis, MO, United States
Apoptosis is a cell-eliminating process in which
unhealthy/unneeded cells are culled in a controlled
manner. Currently, histology is the gold-standard method
for qualifying/quantifying apoptosis. However,
histological techniques require resection and
destruction of the tissue, thus longitudinal
pre-clinical and clinical studies are infeasible. MRI
may offer a non-invasive/non-destructive and
translatable means to detect and quantify apoptosis. We
have initiated such studies by taking advantage of the
high sensitivity afforded by pre-clinical MRI at 11.74 T
with a rodent ethanol-induced apoptosis model. We
observed a 23% signal enhancement in apoptotic cingulate
cortex with T1-weighted imaging 4h after ethanol
injection.
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