Abstract #4289
Quantitative assessment of MRI T 2 response to kainic acid neurotoxicity in rats in vivo
Serguei Liachenko 1 , Jaivijay Ramu 1 , Tetyana Konak 1 , Merle Paule 1 , and Joseph Hanig 2
1
Neurotoxicology, NCTR / FDA, Jefferson, AR,
United States,
2
OTR,
CDER / FDA, White Oak, MD, United States
T
2
mapping
was used to detect the neurotoxicity in the rat brain
caused by acute kainic acid administration. The T
2
changes
were quantified using three methods: 1) simple
threshold; 2) statistical parametric mapping; and 3)
difference with the own baseline. It was shown that
method #3 has the most sensitivity towards the detection
of the neurotoxic changes of the rat brain.
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