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Abstract #4289

Quantitative assessment of MRI T 2 response to kainic acid neurotoxicity in rats in vivo

Serguei Liachenko 1 , Jaivijay Ramu 1 , Tetyana Konak 1 , Merle Paule 1 , and Joseph Hanig 2

1 Neurotoxicology, NCTR / FDA, Jefferson, AR, United States, 2 OTR, CDER / FDA, White Oak, MD, United States

T 2 mapping was used to detect the neurotoxicity in the rat brain caused by acute kainic acid administration. The T 2 changes were quantified using three methods: 1) simple threshold; 2) statistical parametric mapping; and 3) difference with the own baseline. It was shown that method #3 has the most sensitivity towards the detection of the neurotoxic changes of the rat brain.

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