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Abstract #4290

Comparison of Chemical Exchange Saturation Transfer MR Imaging and Diffusion Tensor Imaging in Parkinson's Disease at 3 Tesla

Chunmei Li 1 , Xuna Zhao 2 , Haibo Chen 1 , Jinyuan Zhou 3 , and Min Chen 1

1 Beijing Hospital, Beijing, Beijing, China, 2 Peking University, Beijing, China, 3 Johns Hopkins University, Maryland, United States

This present study is to compare the diagnostic efficiency of CEST imaging and DTI in PD. Our results clearly show that the non-invasive CEST MRI methodology is able to generate unique image contrasts that are based on the changes in cytoplasmic proteins and peptides, as well as the neuronal loss in several specific brain regions in PD patients. For DTI, no significant differences were found for the mean diffusivity (MD) in the five regions between PD patients and normal controls. Decreased fractional anisotropy (FA) was observed only in the substantia nigra in PD patients. Therefore, we got the conclusion that multiple CEST imaging signals could potentially serve as imaging biomarkers to aid in the non-invasive molecular diagnosis of PD and it may apply more information than DTI.

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