Abstract #4290
Comparison of Chemical Exchange Saturation Transfer MR Imaging and Diffusion Tensor Imaging in Parkinson's Disease at 3 Tesla
Chunmei Li 1 , Xuna Zhao 2 , Haibo Chen 1 , Jinyuan Zhou 3 , and Min Chen 1
1
Beijing Hospital, Beijing, Beijing, China,
2
Peking
University, Beijing, China,
3
Johns
Hopkins University, Maryland, United States
This present study is to compare the diagnostic
efficiency of CEST imaging and DTI in PD. Our results
clearly show that the non-invasive CEST MRI methodology
is able to generate unique image contrasts that are
based on the changes in cytoplasmic proteins and
peptides, as well as the neuronal loss in several
specific brain regions in PD patients. For DTI, no
significant differences were found for the mean
diffusivity (MD) in the five regions between PD patients
and normal controls. Decreased fractional anisotropy
(FA) was observed only in the substantia nigra in PD
patients. Therefore, we got the conclusion that multiple
CEST imaging signals could potentially serve as imaging
biomarkers to aid in the non-invasive molecular
diagnosis of PD and it may apply more information than
DTI.
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