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Abstract #4291

Detection of the local volumes of white matter lesions in type 2 diabetes mellitus by an automatic measurement method

Xiaoling Zhang 1 , Bundy Wong 2 , Min Tang 1 , Sipan Chen 1 , Defeng Wang 2 , and Jian Yang 3

1 Department of Radiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China, 2 Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, New Territories, Hong Kong, 3 Department of Radiology, Xi'an Jiao Tong University, Xi'an, Shaanxi, China

The aim of this study was to assess the volumes of white matter lesions (WMLs) of T2DM on MRI using an automatic quantification method, and to explore the relationship of T2DM and WMLs, and some characteristic change of WMLs in T2DM. 26 patients with T2DM and 28 healthy persons underwent MRI including T1WI and FLAIR sequences. The total volume of WMLs in T2DM group, especially volumes of WMLs in bilateral frontal lobes and parietal lobe assessed by an automatic measurement method were significantly larger than those in control group, and HbA1c, Systolic and Diastolic BP were correlated with the WMLs volume in frontal and bilateral parietal lobe in the T2DM group, which maybe associate with the cognitive dysfunction.

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