Writers cramp primary dystonia shows brain gray and white matter alterations: a multimodal imaging study.
Massimo Filippi 1 , Federica Agosta 1 , Lidia Sarro 1 , Aleksandra Tomic 2 , Sebastiano Galantucci 1 , Paola Valsasina 1 , Marina Svetel 2 , Alessandro Sodero 1 , Nikola Kresojevic 2 , Giancarlo Comi 3 , and Vladimir S. Kostic 2
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
of Neurology, Faculty of Medicine, University of
Belgrade, Belgrade, Yugoslavia,
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, Italy
Structural MRI changes were assessed in 19 Writers
Cramp (WC) primary dystonia patients and 30 healthy
controls, analyzing both gray and white matter
differences. WC patients showed a diffuse pattern of
cortical volume and area increase, as well as a diffuse
pattern of WM damage involving both sensorimotor and
extra-sensorimotor regions. These findings suggest a
complex network dysfunction playing a role in the
development of focal hand dystonia. Structural and DT
MRI hold promise to achieve a better in vivo
understanding of such an enigmatic disease.
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