Abstract #4300
Altered hippocampal white matter connectivity and memory impairment in Type 2 Diabetes Mellitus
Frank C.G. van Bussel 1 , Walter H. Backes 1 , Paul A.M. Hofman 1 , Alfons G.H. Kessels 2 , Tamar M. van Veenendaal 1 , Harm J. van de Haar 1 , Martin P.J. van Boxtel 3 , Miranda T. Schram 4 , Coen D.A. Stehouwer 4 , Joachim E. Wildberger 1 , and Jacobus F.A. Jansen 1
1
Radiology, Maastricht University Medical
Center, Maastricht, Limburg, Netherlands,
2
Clinical
Epidemiology and Medical Technology Assessment,
Maastricht University Medical Center, Maastricht,
Limburg, Netherlands,
3
Psychiatry
and Neuropsychology, Maastricht University Medical
Center, Maastricht, Limburg, Netherlands,
4
Internal
Medicine, Maastricht University Medical Center,
Maastricht, Limburg, Netherlands
Type 2 Diabetes Mellitus (T2DM) is associated with
cognitive decline. A prominently affected cognitive
domain is memory, for which the hippocampus is
essential. Diffusion MRI enables assessment of
hippocampal microstructure through the fractional
anisotropy, mean diffusivity, and tractographic
connectivity. This study showed that T2DM participants
have less hippocampal connectivity to the frontal lobe.
In addition, impaired memory performance correlated with
the altered hippocampal connectivity to the temporal and
parietal lobes.
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