Abstract #4301
Neuromelanin-sensitive imaging correlates of idiopathic rapid eye movement sleep behavior disorders
Mickael Ehrminger 1 , Alice Latimier 2 , Daniel Garcia-Lorenzo 3 , Smaranda Leu-Semenescu 4 , Marie Vidailhet 5 , Isabelle Arnulf 4 , and Stephane Lehericy 6
1
Ecole Normale Superieure, Paris, France,
2
Service
des pathologies du sommeil, ICM - Institut du Cerveau et
de la Moelle, Paris, France,
3
CENIR
- Centre for NeuroImaging Research, ICM - Institut du
Cerveau et de la Moelle, Paris, France,
4
Service
des pathologies du sommeil, Hopital Pitie-Salpetriere,
Paris, France,
5
Service de Neurologie, ICM -
Institut du Cerveau et de la Moelle, Paris, France,
6
CENIR
- Center for NeuroImaging Research, ICM - Institut du
Cerveau et de la Moelle, Paris, France
Rapid eye movement (REM) sleep behavior disorders (RBD)
are symptoms of nocturnal violence that occur in
isolation in patients with idiopathic RBD (iRBD) and are
considered a premotor sign of parkinsonism. We show
reduced signal intensity in the locus
coeruleus/subcoeruleus complex (LCSC) using
neuromelanin-sensitive MRI in iRBD that correlated with
the percentage of atonia during REM sleep. These results
suggest that the LCSC complex is involved in the
pathophysiology of iRBD.
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