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Abstract #4304

Magnetic Resonance Spectroscopy in the Motor and Sensory Cortices following Surgery for Cervical Spondylotic Myelopathy

Sandy Goncalves 1,2 , Todd K Stevens 2 , Robert Bartha 1,2 , and Neil Duggal 1,3

1 Medical Biophysics, Western University, London, Ontario, Canada, 2 Centre for Functional and Metabolic Mapping, Robarts Research Institute - Western University, London, Ontario, Canada, 3 Clinical Neurological Sciences, University Hospital - London Health Sciences Centre, London, Ontario, Canada

Surgical outcome for patients suffering from cervical spondylotic myelopathy (CSM) is unpredictable with varying motor and sensory symptom recovery. We show that absolute NAA levels are lower in CSM patients compared to controls in motor and sensory cortex and that following spinal decompression surgery absolute NAA levels decrease in a similar temporal pattern but in the opposite direction as clinical motor and sensory function. This finding suggests that low NAA levels may be a benefit for functional recovery although the neural mechanisms involved have not been elucidated.

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