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Abstract #4305

Chemical Exchange Saturation Transfer MR Imaging of Alzheimers Disease at 3 Tesla: a Preliminary study

Rui Wang 1 , Saying Li 1 , Min Chen 1 , Jinyuan Zhou 2 , Dantao Peng 3 , Chen Zhang 1 , and Yongming Dai 4

1 Department of Radiology, Beijing Hospital, Beijing, Beijing, China, 2 Johns Hopkins University School of Medicine, Maryland, United States, 3 Department of Neurology, China-Japan Friendship Hospital, Beijing, Beijing, China, 4 Philips Healthcare, Shanghai, China

Our aim is to evaluate the feasibility of Amide proton transfer (APT) imaging to detect cerebral abnormality in Alzheimers disease (AD) patients. Twenty AD patients and 20 normal controls were enrolled for APT imaging. The magnetic resonance ratio asymmetry (MTRasym) at 3.5ppm of bilateral hippocampi, temporal white matter regions, occipital white matter regions and cerebral peduncles were measured. We found that MTRasym(3.5ppm) of bilateral hippocampi were increased in AD patients than normal controls. MTRasym(3.5ppm) of bilateral hippocampi were negatively correlated with MMSE. Our results suggested that APT imaging could potentially provide imaging biomarkers for the non-invasive molecular diagnosis of AD.

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