Abstract #4305
Chemical Exchange Saturation Transfer MR Imaging of Alzheimers Disease at 3 Tesla: a Preliminary study
Rui Wang 1 , Saying Li 1 , Min Chen 1 , Jinyuan Zhou 2 , Dantao Peng 3 , Chen Zhang 1 , and Yongming Dai 4
1
Department of Radiology, Beijing Hospital,
Beijing, Beijing, China,
2
Johns
Hopkins University School of Medicine, Maryland, United
States,
3
Department
of Neurology, China-Japan Friendship Hospital, Beijing,
Beijing, China,
4
Philips
Healthcare, Shanghai, China
Our aim is to evaluate the feasibility of Amide proton
transfer (APT) imaging to detect cerebral abnormality in
Alzheimers disease (AD) patients. Twenty AD patients
and 20 normal controls were enrolled for APT imaging.
The magnetic resonance ratio asymmetry (MTRasym) at
3.5ppm of bilateral hippocampi, temporal white matter
regions, occipital white matter regions and cerebral
peduncles were measured. We found that MTRasym(3.5ppm)
of bilateral hippocampi were increased in AD patients
than normal controls. MTRasym(3.5ppm) of bilateral
hippocampi were negatively correlated with MMSE. Our
results suggested that APT imaging could potentially
provide imaging biomarkers for the non-invasive
molecular diagnosis of AD.
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