Abstract #4307
The Prospectively Validated RfMRI Biomarkers for Mild Cognitive Impairment
Gang Chen 1 , Hao Shu 1,2 , Guangyu Chen 1 , Wenjun Li 3 , Zhan Xu 1 , Zan Wang 2 , Duan Liu 2 , B. Douglas Ward 1 , Jennifer Jones 4 , Malgorzata Franczak 4 , Joseph Goveas 3 , Piero Antuono 4 , Zhijun Zhang 2 , and Shi-Jiang Li 1
1
Biophysics, Medical College of Wisconsin,
milwaukee, WI, United States,
2
Neurology,
Affiliated ZhongDa Hospital of Southeast University,
China,
3
Psychiatry,
Medical College of Wisconsin, milwaukee, WI, United
States,
4
Neurology,
Medical College of Wisconsin, Milwaukee, WI, United
States
The RfMRI data were collected through an international
collaboration effort across 17 imaging sites. The
imaging biomarkers for mild cognitive impairment (MCI)
were obtained from 217 subjects (110 cognitively normal
(CN) and 107 MCI). To test whether the biomarkers can be
applied to the prospective studies, another set of RfMRI
data were obtained from 217 disjoint subjects. The
results showed that the RfMRI biomarkers were validated
on the prospective data set (p<0.004). The RfMRI
biomarkers were found to be robust, reliable and can be
applied to prospective studies.
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