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Abstract #4307

The Prospectively Validated RfMRI Biomarkers for Mild Cognitive Impairment

Gang Chen 1 , Hao Shu 1,2 , Guangyu Chen 1 , Wenjun Li 3 , Zhan Xu 1 , Zan Wang 2 , Duan Liu 2 , B. Douglas Ward 1 , Jennifer Jones 4 , Malgorzata Franczak 4 , Joseph Goveas 3 , Piero Antuono 4 , Zhijun Zhang 2 , and Shi-Jiang Li 1

1 Biophysics, Medical College of Wisconsin, milwaukee, WI, United States, 2 Neurology, Affiliated ZhongDa Hospital of Southeast University, China, 3 Psychiatry, Medical College of Wisconsin, milwaukee, WI, United States, 4 Neurology, Medical College of Wisconsin, Milwaukee, WI, United States

The RfMRI data were collected through an international collaboration effort across 17 imaging sites. The imaging biomarkers for mild cognitive impairment (MCI) were obtained from 217 subjects (110 cognitively normal (CN) and 107 MCI). To test whether the biomarkers can be applied to the prospective studies, another set of RfMRI data were obtained from 217 disjoint subjects. The results showed that the RfMRI biomarkers were validated on the prospective data set (p<0.004). The RfMRI biomarkers were found to be robust, reliable and can be applied to prospective studies.

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