Abstract #4308
Structural and functional connectivity in Dementia with Lewy Bodies compared to Alzheimer Disease
Vanda Viola 1 , Laura Serra 1 , Elisa Tuzzi 1 , Chiara Mastropasqua 1 , Barbara Span 1 , Barbara Basile 1 , Mario Torso 1 , Giovanni Giulietti 1 , Elena Makovac 1 , Camillo Marra 2 , Mara Cercignani 3 , Carlo Caltagirone 4,5 , and Marco Bozzali 1
1
Neuroimaging Laboratory, Santa Lucia
Foundation IRCCS, Roma, RM, Italy,
2
Institute
of Neurology, Universit Cattolica, Rome, Italy,
3
Clinical
Imaging Science Centre, Brighton and Sussex Medical
School, Brighton, United Kingdom,
4
Departmente
of Clinical and Behavioral Neurology, Santa Lucia
Foundation IRCCS, Rome, Italy,
5
Department
of Neuroscience, Universit "Tor Vergata", Rome, Italy
Clinical Symptoms can often overlap between Alzheimer
Disease (AD) and Dementia with Lewy Body (DLB), and this
can cause delayed or incorrect diagnosis. The aim of the
present investigation was to detect dissimilarities
between AD and DLBs structural and functional
connectivity. Specifically, structural connectivity was
analyzed in the inferior frontal occipital fasciculus
and in the superior cingulum bundle using diffusion
tractography, while functional connectivity was explored
in the left and right fronto-parietal networks during
resting state. Our results highlighted that structural
and functional connectivity were altered in both
hemispheres in AD and only in the right hemisphere in
DLB patients.
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