Meeting Banner
Abstract #4308

Structural and functional connectivity in Dementia with Lewy Bodies compared to Alzheimer Disease

Vanda Viola 1 , Laura Serra 1 , Elisa Tuzzi 1 , Chiara Mastropasqua 1 , Barbara Span 1 , Barbara Basile 1 , Mario Torso 1 , Giovanni Giulietti 1 , Elena Makovac 1 , Camillo Marra 2 , Mara Cercignani 3 , Carlo Caltagirone 4,5 , and Marco Bozzali 1

1 Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Roma, RM, Italy, 2 Institute of Neurology, Universit Cattolica, Rome, Italy, 3 Clinical Imaging Science Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 4 Departmente of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy, 5 Department of Neuroscience, Universit "Tor Vergata", Rome, Italy

Clinical Symptoms can often overlap between Alzheimer Disease (AD) and Dementia with Lewy Body (DLB), and this can cause delayed or incorrect diagnosis. The aim of the present investigation was to detect dissimilarities between AD and DLBs structural and functional connectivity. Specifically, structural connectivity was analyzed in the inferior frontal occipital fasciculus and in the superior cingulum bundle using diffusion tractography, while functional connectivity was explored in the left and right fronto-parietal networks during resting state. Our results highlighted that structural and functional connectivity were altered in both hemispheres in AD and only in the right hemisphere in DLB patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here