Abstract #4309
White Matter Abnormalities in Type-2 Diabetes Patients with Mild Cognitive Impairment: A Diffusion Tensor Imaging Study
Ying Xiong 1,2 , Yi Sui 2 , Zhipeng Xu 3 , Shiqi Yang 1 , Kejia Cai 2,4 , Wenzhen Zhu 1 , and Xiaohong Joe Zhou 2,4
1
Department of Radiology, Tongji Hospital,
Tongji Medical College, Huazhong University of Science
and Technology, Wuhan, Hubei, China,
2
Center
for MR Research, University of Illinois at Chicago,
Chicago, IL, United States,
3
Pathophysiology
Department, Tongji Medical College, Huazhong University
of Science and Technology, Wuhan, Hubei, China,
4
Department
of Radiology, University of Illinois at Chicago,
Chicago, IL, United States
This study aims at studying the white matter alterations
in type 2 diabetes mellitus (T2DM) patients and the
relationship with cognitive impairment using DTI. Forty
two T2DM patients were divided into two groups based on
their cognition status, and imaged along with healthy
controls. It was found that the white matter changes
were associated more closely to cognition than to
diabetes. Compromised myelin sheath may explain changes
in DTI parameters observed in T2DM patients with
cognitive impairment. It was also observed that there
was no difference in FA and MD between the diabetes
patients with normal cognition and the controls.
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