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Abstract #4309

White Matter Abnormalities in Type-2 Diabetes Patients with Mild Cognitive Impairment: A Diffusion Tensor Imaging Study

Ying Xiong 1,2 , Yi Sui 2 , Zhipeng Xu 3 , Shiqi Yang 1 , Kejia Cai 2,4 , Wenzhen Zhu 1 , and Xiaohong Joe Zhou 2,4

1 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 2 Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, 3 Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 4 Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States

This study aims at studying the white matter alterations in type 2 diabetes mellitus (T2DM) patients and the relationship with cognitive impairment using DTI. Forty two T2DM patients were divided into two groups based on their cognition status, and imaged along with healthy controls. It was found that the white matter changes were associated more closely to cognition than to diabetes. Compromised myelin sheath may explain changes in DTI parameters observed in T2DM patients with cognitive impairment. It was also observed that there was no difference in FA and MD between the diabetes patients with normal cognition and the controls.

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