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Abstract #4316

Deterioration from Healthy to Mild Cognitive Impairment and Alzheimers disease Mirrored in Corresponding Loss of Centrality in Directed Brain Networks

Sinan Zhao 1 , CK Dharmendra Kumar 2 , D Narayana Dutt 2 , Peipeng Liang 3,4 , and Gopikrishna Deshpande 1,5

1 AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2 Department of Medical Electronics, Dayananda Sagar College of Engineering, Bangalore, India, 3 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 4 Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing, China, 5 Department of Psychology, Auburn University, Auburn, AL, United States

We estimated Betweenness Centrality (BC) from directed networks derived from the application of Granger causality to resting state fMRI data acquired from: Normal Control (NC), Early MCI (EMCI), Late MCI (LMCI) and Alzheimers disease (AD). We used an additional metric called middlemen power (MP) which not only characterizes information flow through a node as in BC, but also estimates the power of the node in terms of its criticality for information flow in the entire network. We found that BC and MP of a few brain regions progressively decreased from NC to EMCI to LMCI to AD.

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