Abstract #4316
Deterioration from Healthy to Mild Cognitive Impairment and Alzheimers disease Mirrored in Corresponding Loss of Centrality in Directed Brain Networks
Sinan Zhao 1 , CK Dharmendra Kumar 2 , D Narayana Dutt 2 , Peipeng Liang 3,4 , and Gopikrishna Deshpande 1,5
1
AU MRI Research Center, Department of
Electrical and Computer Engineering, Auburn University,
Auburn, AL, United States,
2
Department
of Medical Electronics, Dayananda Sagar College of
Engineering, Bangalore, India,
3
Department
of Radiology, Xuanwu Hospital, Capital Medical
University, Beijing, China,
4
Beijing
Key Laboratory of Magnetic Resonance Imaging and Brain
Informatics, Key Laboratory for Neurodegenerative
Diseases, Ministry of Education, Beijing, China,
5
Department
of Psychology, Auburn University, Auburn, AL, United
States
We estimated Betweenness Centrality (BC) from directed
networks derived from the application of Granger
causality to resting state fMRI data acquired from:
Normal Control (NC), Early MCI (EMCI), Late MCI (LMCI)
and Alzheimers disease (AD). We used an additional
metric called middlemen power (MP) which not only
characterizes information flow through a node as in BC,
but also estimates the power of the node in terms of its
criticality for information flow in the entire network.
We found that BC and MP of a few brain regions
progressively decreased from NC to EMCI to LMCI to AD.
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