Abstract #4317
Brain T1rho MR imaging in Parkinson Disease: Female vs Male
Santosh K. Yadav 1 , Anup Singh 2,3 , Arshi Rizwan 4 , Christos Davatzikos 5 , Elias R. Melhem 6 , Deepak Kaura 1 , Ena Wang 1 , Francesco M. Marincola 1 , and Mohammad Haris 1,2
1
Research Branch, Sidra Medical and Research
Center, Doha, Qatar,
2
Radiology,
Center for Magnetic Resonance and Optical Imaging,
University of Pennsylvania, Philadelphia, PA, United
States,
3
Center
for Biomedical Engineering, Indian Institute of
Technology, New Delhi, India,
4
All
India Institute of Medical sciences, New Delhi, India,
5
Section
of Biomedical Image Analysis, University of
Pennsylvania, Philadelphia, PA, United States,
6
Department
of Diagnostic Radiology and Nuclear Medicine, University
of Maryland Medical Center, MD, United States
In the current study, we have measured the gender based
changes in the T1ρ relaxation time in
medial-temporal-lobe and hippocampus in brain of
Parkinson's disease (PD) patients. Larger changes in T1ρ
relaxation in female PD patients were observed compared
to male PD patients. This change in T1ρ might be
attributed to the physiological and genomic differences
between male and female, and may provide a clinical
measure to differentiate the severity of disease and
outcome of the treatment responses among gender.
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