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Abstract #4317

Brain T1rho MR imaging in Parkinson Disease: Female vs Male

Santosh K. Yadav 1 , Anup Singh 2,3 , Arshi Rizwan 4 , Christos Davatzikos 5 , Elias R. Melhem 6 , Deepak Kaura 1 , Ena Wang 1 , Francesco M. Marincola 1 , and Mohammad Haris 1,2

1 Research Branch, Sidra Medical and Research Center, Doha, Qatar, 2 Radiology, Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 3 Center for Biomedical Engineering, Indian Institute of Technology, New Delhi, India, 4 All India Institute of Medical sciences, New Delhi, India, 5 Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, United States, 6 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland Medical Center, MD, United States

In the current study, we have measured the gender based changes in the T1ρ relaxation time in medial-temporal-lobe and hippocampus in brain of Parkinson's disease (PD) patients. Larger changes in T1ρ relaxation in female PD patients were observed compared to male PD patients. This change in T1ρ might be attributed to the physiological and genomic differences between male and female, and may provide a clinical measure to differentiate the severity of disease and outcome of the treatment responses among gender.

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