Abstract #4318
Apolipoprotein E ε4 genotype is associated with the changes in cortical thickness and CSF biomarkers in mild cognitive impairment and Alzheimers disease
Santosh K. Yadav 1 , Anup Singh 2,3 , Arshi Rizwan 4 , Christos Davatzikos 5 , Elias R. Melhem 6 , Deepak Kaura 1 , Ena Wang 1 , Francesco M. Marincola 1 , and Mohammad Haris 1,2
1
Research Branch, Sidra Medical and Research
Center, Doha, Qatar,
2
Radiology,
Center for Magnetic Resonance and Optical Imaging,
University of Pennsylvania, Philadelphia, PA, United
States,
3
Center
for Biomedical Engineering, Indian institute of
Technology, New Delhi, India,
4
All
India Institute of Medical sciences, New Delhi, India,
5
Section
of Biomedical Image Analysis, University of
Pennsylvania, Philadelphia, PA, United States,
6
Department
of Diagnostic Radiology and Nuclear Medicine, University
of Maryland Medical Center, MD, United States
ApoE ε4 allele has been identified as a major risk
factor for Alzheimers disease (AD). In the current
study, reduced cortical thickness in various brain's
regions was observed in mild cognitive (MCI) impairment
and Alzheimers disease (AD), when compared with
controls. MCI and AD with ApoE ε4 carriers showed
greater reduction in cortical thicknesses than
non-carriers. The pathological mechanisms contributing
to reduced cortical thicknesses likely include loss of
neurons and other supporting cells.
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