Abstract #4319
Differential MRI Relaxation in Alzheimers Patients with Mutant HFE and Transferrin Genotypes
Mark David Meadowcroft 1,2 , Douglas G Peters 1,3 , Carson J Purnell 1 , Jian-Li Wang 2 , Paul J Eslinger 4 , Megha Vasavada 2 , Qing X Yang 2 , and James R Connor 1
1
Neurosurgery, The Pennsylvania State
University - College of Medicine, Hershey, Pennsylvania,
United States,
2
Radiology,
The Pennsylvania State University - College of Medicine,
Hershey, Pennsylvania, United States,
3
Neural
and Behavioral Sciences, The Pennsylvania State
University - College of Medicine, Hershey, Pennsylvania,
United States,
4
Neurology,
The Pennsylvania State University - College of Medicine,
Hershey, Pennsylvania, United States
Iron accumulation in the brain and oxidative stress are
observed in a number of neurodegenerative disorders,
such as Alzheimers disease (AD). AD patients were
stratified based on their HFE (H63D and C282Y) and
transferrin (C2) gene carrier status and had statistical
parametrics transverse relaxation analysis completed. AD
patients who are carriers of H63D, C282Y, and/or C2
mutations exhibit a widespread increase in transverse
relaxation within white matter association fibers across
the brain. This pattern is indicative of white matter
alterations in AD, congruent with the hypothesis and
data showing that AD has an integral white matter
component.
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