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Abstract #4321

Double Inversion Recovery Imaging Improves to Evaluate Brain Tissue Volume Loss in Patients with Alzheimers Disease Compared to That of 3D T1-weighted Imaging

Geon-Ho Jahng 1 , Danbi Kim 1 , Soonchan Park 1 , Dong Kyun Lee 2 , Jong-Min Lee 2 , Hak Young Rhee 3 , Chang-Woo Ryu 1 , Jang-Hoon Oh 4 , Hyug-Gi Kim 4 , and Dal-Mo Yang 1

1 Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Seoul, Korea, 2 Biomedical Engineering, Hanyang University, Seoul, Seoul, Korea, 3 Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Seoul, Korea, 4 Biomedical Engineering, Kyung Hee University, Suwon, Gyeonggi-do, Korea

To gray matter volume (GMV) loss with double inversion recovery (DIR) in patients with Alzheimers disease (AD), we included 25 mild or probable AD, 25 amnestic mild cognitive impairment (MCI), and 25 elderly cognitive normal (CN) subjects. Both 3D DIR and 3D T1W images were acquired. GMV loss in the AD group compared with CN or MCI group was depicted in both DIR and 3DT1W images. However, DIR was much more sensitive to evaluate GMV loss compared to 3DT1W. With DIR, GMV loss in AD compared with CN and MCI was showed in the temporal and frontal areas.

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