Abstract #4321
Double Inversion Recovery Imaging Improves to Evaluate Brain Tissue Volume Loss in Patients with Alzheimers Disease Compared to That of 3D T1-weighted Imaging
Geon-Ho Jahng 1 , Danbi Kim 1 , Soonchan Park 1 , Dong Kyun Lee 2 , Jong-Min Lee 2 , Hak Young Rhee 3 , Chang-Woo Ryu 1 , Jang-Hoon Oh 4 , Hyug-Gi Kim 4 , and Dal-Mo Yang 1
1
Radiology, Kyung Hee University Hospital at
Gangdong, Seoul, Seoul, Korea,
2
Biomedical
Engineering, Hanyang University, Seoul, Seoul, Korea,
3
Neurology,
Kyung Hee University Hospital at Gangdong, Seoul, Seoul,
Korea,
4
Biomedical
Engineering, Kyung Hee University, Suwon, Gyeonggi-do,
Korea
To gray matter volume (GMV) loss with double inversion
recovery (DIR) in patients with Alzheimers disease
(AD), we included 25 mild or probable AD, 25 amnestic
mild cognitive impairment (MCI), and 25 elderly
cognitive normal (CN) subjects. Both 3D DIR and 3D T1W
images were acquired. GMV loss in the AD group compared
with CN or MCI group was depicted in both DIR and 3DT1W
images. However, DIR was much more sensitive to evaluate
GMV loss compared to 3DT1W. With DIR, GMV loss in AD
compared with CN and MCI was showed in the temporal and
frontal areas.
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