Searching for new Dementia-related Features within MRI: Keypoint Detection and Description

New dementia-related features are presented to differentiate between various stages of Alzheimers disease. Prior registration of MRI-scans, possibly unsuccessful and always time-consuming, is avoided by employing local invariant features which are independent of image scale and orientation. Feature detectors are implemented based on scale-space theory in an automatized image processing workflow, and tested on a standardized MRI collection comprising 382 T1 MRI scans from patients with Alzheimer's Disease or mild cognitive impairment, and from a control group. The approach is not only very efficient for processing large datasets, but also first order statistics of features already differentiate significantly between classes.

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