Abstract #4328
Investigating haemodynamic changes in the default mode network in Alzheimers Disease
Richard J. Dury 1 , Latha Velayudhan 2 , Penny A. Gowland 1 , and Susan T. Francis 1
1
Sir Peter Mansfield Imaging Centre, The
University of Nottingham, Nottingham, United Kingdom,
2
Department
of Health Sciences, Leicester General Hospital,
Leicester, United Kingdom
We investigate haemodynamic changes in Alzheimers
Disease (AD) and how this relates to resting state
network (RSN) activity. Using Arterial Spin Labelling at
multiple post-label delay times we assess cerebral blood
flow and tissue transit time changes in AD patients and
an age-matched healthy control (HC) group. CBF is found
to be reduced in AD compared to the HC group, with a
trend for increased in TTT. In the default mode network
(DMN) nodes of the inferior parietal lobe (IPL) a
significant reduction in CBF is found. However, changes
in CBF were not linked to altered network activity.
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