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Abstract #4328

Investigating haemodynamic changes in the default mode network in Alzheimers Disease

Richard J. Dury 1 , Latha Velayudhan 2 , Penny A. Gowland 1 , and Susan T. Francis 1

1 Sir Peter Mansfield Imaging Centre, The University of Nottingham, Nottingham, United Kingdom, 2 Department of Health Sciences, Leicester General Hospital, Leicester, United Kingdom

We investigate haemodynamic changes in Alzheimers Disease (AD) and how this relates to resting state network (RSN) activity. Using Arterial Spin Labelling at multiple post-label delay times we assess cerebral blood flow and tissue transit time changes in AD patients and an age-matched healthy control (HC) group. CBF is found to be reduced in AD compared to the HC group, with a trend for increased in TTT. In the default mode network (DMN) nodes of the inferior parietal lobe (IPL) a significant reduction in CBF is found. However, changes in CBF were not linked to altered network activity.

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