Imaging biomarker and pathophysiology of early memory impairment in multiple sclerosis: a pre-clinical study with diffusion-tensor imaging of hippocampal layers.
Thomas Tourdias 1,2 , Vincent Planche 1 , Bassem Hiba 3 , Aline Desmedt 1 , Gerard Raffard 3 , Aude Panatier 1 , Stphane Oliet 1 , and Vincent Dousset 1,2
INSERM U862 Neurocentre Magendie, University
of Bordeaux, Bordeaux, France,
of Neuroradiology, Bordeaux University hospital,
UMR CNRS 5536, University
of Bordeaux, Bordeaux, France
Early memory impairment was demonstrated in experimental
autoimmune encephalomyelitis (EAE), the animal model of
multiple sclerosis. High-resolution DTI showed a
selective decrease of FA in the molecular layer (ML) of
the dentate gyrus of the cognitively-impaired EAE-mice
compared to controls. While there was diffuse
hippocampal microglia activation, a selective dendritic
loss and neuronal death in the ML of the dentate gyrus
were the main correlate of the low FA in EAE-mice.
Treatment with the microglia inhibitor minocycline
protected against this neurodegenerative process and
prevented memory impairment; the effect being measurable
as an increase of FA in treated-mice compared to
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