SWI lesion load and tissue hypoxia in multiple sclerosis: a study using the experimental autoimmune encephalomyelitis animal model at 9.4T
Raveena Dhaliwal 1 , Nabeela Nathoo 1 , Ying Wu 1 , James A. Rogers 2 , V. Wee Yong 2 , and Jeff F. Dunn 1
Radiology, University of Calgary, Calgary,
Neurosciences, University of Calgary, Calgary, Alberta,
Susceptibility weighted MRI has been used to detect
hypointensities in MS and animal models of MS. We showed
that, in the experimental autoimmune encephalopathy
(EAE) model of MS, many hypointensities were caused by
deoxyhemoglobin. We hypothesized that this indicated
hypoxia. To determine if hypoxia was present in spinal
cords of EAE mice, we used MRI SWI at 9.4T to detect
hypointensities and pimonidazole to detect hypoxia.
Hypoxia and hypointensities were observed in day 7 and
20 EAE mice. Inflammation was seen at day 20. We
concluded that tissue and venous hypoxia can occur prior
to onset of symptoms in EAE.
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