Meeting Banner
Abstract #4330

SWI lesion load and tissue hypoxia in multiple sclerosis: a study using the experimental autoimmune encephalomyelitis animal model at 9.4T

Raveena Dhaliwal 1 , Nabeela Nathoo 1 , Ying Wu 1 , James A. Rogers 2 , V. Wee Yong 2 , and Jeff F. Dunn 1

1 Radiology, University of Calgary, Calgary, Alberta, Canada, 2 Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

Susceptibility weighted MRI has been used to detect hypointensities in MS and animal models of MS. We showed that, in the experimental autoimmune encephalopathy (EAE) model of MS, many hypointensities were caused by deoxyhemoglobin. We hypothesized that this indicated hypoxia. To determine if hypoxia was present in spinal cords of EAE mice, we used MRI SWI at 9.4T to detect hypointensities and pimonidazole to detect hypoxia. Hypoxia and hypointensities were observed in day 7 and 20 EAE mice. Inflammation was seen at day 20. We concluded that tissue and venous hypoxia can occur prior to onset of symptoms in EAE.

This abstract and the presentation materials are available to members only; a login is required.

Join Here