Abstract #4335
Dynamic changes in venous susceptibility in the spinal cord of an animal model of MS are detected with susceptibility-weighted imaging
Nabeela Nathoo 1,2 , Ying Wu 1 , James A. Rogers 2,3 , V. Wee Yong 2,3 , and Jeff F. Dunn 1,4
1
Radiology, University of Calgary, Calgary,
Alberta, Canada,
2
Hotchkiss
Brain Institute, University of Calgary, Calgary,
Alberta, Canada,
3
Clinical
Neurosciences, University of Calgary, Calgary, Alberta,
Canada,
4
Experimental
Imaging Centre, University of Calgary, Calgary, Alberta,
Canada
We showed previously that susceptibility weighted
imaging (SWI) detects hypointensities due to
intravascular deoxyhemoglobin in the experimental
autoimmune encephalomyelitis (EAE) model of multiple
sclerosis (MS) during peak motor dysfunction. In this
study, we characterized the time course of SWI lesion
load as a biomarker of reduced venous oxygenation over
the EAE disease course. Two main observations emerged:
1) changes in venous oxygenation may precede the onset
of motor dysfunction in EAE mice; and 2) maximum SWI
lesion load occurred before or coincided with maximum
motor dysfunction. SWI could be used to shed light on
venous oxygenation in EAE and MS.
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