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Abstract #4335

Dynamic changes in venous susceptibility in the spinal cord of an animal model of MS are detected with susceptibility-weighted imaging

Nabeela Nathoo 1,2 , Ying Wu 1 , James A. Rogers 2,3 , V. Wee Yong 2,3 , and Jeff F. Dunn 1,4

1 Radiology, University of Calgary, Calgary, Alberta, Canada, 2 Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada, 3 Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, 4 Experimental Imaging Centre, University of Calgary, Calgary, Alberta, Canada

We showed previously that susceptibility weighted imaging (SWI) detects hypointensities due to intravascular deoxyhemoglobin in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) during peak motor dysfunction. In this study, we characterized the time course of SWI lesion load as a biomarker of reduced venous oxygenation over the EAE disease course. Two main observations emerged: 1) changes in venous oxygenation may precede the onset of motor dysfunction in EAE mice; and 2) maximum SWI lesion load occurred before or coincided with maximum motor dysfunction. SWI could be used to shed light on venous oxygenation in EAE and MS.

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