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Abstract #4334

Describing the distribution of myelin water fraction change among early stage MS lesions

Elizabeth Monohan 1 , Wendy Vargas 1 , Sneha Pandya 2 , Michael Dayan 2 , Thanh Nguyen 2 , Ashish Raj 2 , Sandra Hurtado 3 , and Susan Gauthier 1

1 Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, United States, 2 Radiology, Weill Cornell Medical College, New York, NY, United States, 3 Public Health, Weill Cornell Medical College, New York, New York, United States

Our study utilized FAST-T2, a T2-relaxometry technique, to study myelin water fraction (MWF) within two types of early MS lesions: enhancing and new non-enhancing T2 lesions. Additionally, we exploited the T2 spectrum and utilized a novel approach to measure resolving edema within these lesions types. Enhancing lesions showed a greater and more variable change in MWF on follow up scan versus new non-enhancing lesions.

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