Abstract #4333
Cerebral blood flow modulation insufficiency in default mode network in multiple sclerosis: a hypercapnia MRI study
Olga Marshall 1 , Sanjeev Chawla 1 , Hanzhang Lu 2 , Ilya Kister 3 , Jacqueline Smith 1 , and Yulin Ge 1
1
Radiology/Center for Biomedical Imaging, New
York University School of Medicine, New York, NY, United
States,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, TX, United States,
3
Neurology,
New York University School of Medicine, New York, NY,
United States
The default mode network (DMN) is a well-established and
critical network, which has been shown to be associated
with healthy cognitive function and is known to be
disrupted in various neurological conditions, including
multiple sclerosis (MS). Cerebrovascular reactivity
(CVR) is a measure of healthy neurovascular coupling and
overall brain function. In this study, we quantify the
CVR deficit seen within the DMN, in order to shed some
light on the cognitive deficits that MS patients often
experience.
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