Abstract #4332

Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone-induced demyelination and spontaneous remyelination

Caroline Guglielmetti ¹ , Jelle Veraart ² , Ella Roelant ³ , Zhenhua Mai ⁴ , Jasmijn Daans ⁵ , Johan Van Audekerke ⁴ , Jelle Praet ⁴ , Peter Ponsaerts ⁵ , jan Sijbers ² , Annemie Van der Linden ⁴ , and Marleen Verhoye ⁴

¹ Bio Imaging Lab, University of Antwerp, WILRIJK, ANTWERPEN, Belgium, ² IBBT Vision LaboratoryDepartment of Physics, University of Antwerp, ANTWERPEN, Belgium, ³ StatUa Center for Statistics, University of Antwerp, ANTWERPEN, Belgium, ⁴ Bio Imaging Lab, University of Antwerp, ANTWERPEN, Belgium, ⁵ Experimental Cell Transplantation Group, Laboratory of Experimental Hematology, Vaccine and Infect, ANTWERPEN, Belgium

Sensitivity of diffusion kurtosis imaging (DKI) to detect microstructural alterations has been demonstrated in patients suffering from several neurological disorders. Despite advances in neuroimaging techniques, the majority of cortical alterations present in multiple sclerosis patients still fail to be detected. In this work, we used the well characterized cuprizone mouse model for brain demyelination and evaluated the sensitivity of in vivo DKI measurements for the non-invasive detection of cortical grey matter and white matter alterations. We showed that DKI can probe cortical demyelination and allow the detection of white matter inflammation and demyelination following cuprizone administration.

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