Abstract #4338
In-vivo measurement of cerebral metabolic rate of oxygen consumption in an animal model of multiple sclerosis using combined MRI and near-infrared spectroscopy
Thomas W. Johnson 1,2 , Linhui Yu 3 , Kartikeya Murari 3 , and Jeff F. Dunn 1,2
1
Radiology, University of Calgary, Calgary,
Alberta, Canada,
2
Hotchkiss
Brain Institute, Calgary, Alberta, Canada,
3
Electrical
Engineering, University of Calgary, Calgary, Alberta,
Canada
Cerebral metabolic rate of oxygen consumption was
measured in the cortex of mice with long term (day 36
post induction) experimental autoimmune
encephalomyelitis, a model of multiple sclerosis. A
multimodal MRI / near-infrared spectroscopy system was
used to measure cerebral blood flow and capillary
hemoglobin saturation respectively. Arterial saturation
was monitored using a pulse oximeter. The control mice
(n=8) were found to have a CMRO2 of 2.69 0.84 mL mol
O2/g/min, and the experimental mice (n=3) be 6.09 1.14
mol O2/g/min, with p < 0.001. This abnormal metabolism
could be due to uncoupled mitochondria, and may point to
neurodegeneration.
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