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Abstract #4338

In-vivo measurement of cerebral metabolic rate of oxygen consumption in an animal model of multiple sclerosis using combined MRI and near-infrared spectroscopy

Thomas W. Johnson 1,2 , Linhui Yu 3 , Kartikeya Murari 3 , and Jeff F. Dunn 1,2

1 Radiology, University of Calgary, Calgary, Alberta, Canada, 2 Hotchkiss Brain Institute, Calgary, Alberta, Canada, 3 Electrical Engineering, University of Calgary, Calgary, Alberta, Canada

Cerebral metabolic rate of oxygen consumption was measured in the cortex of mice with long term (day 36 post induction) experimental autoimmune encephalomyelitis, a model of multiple sclerosis. A multimodal MRI / near-infrared spectroscopy system was used to measure cerebral blood flow and capillary hemoglobin saturation respectively. Arterial saturation was monitored using a pulse oximeter. The control mice (n=8) were found to have a CMRO2 of 2.69 0.84 mL mol O2/g/min, and the experimental mice (n=3) be 6.09 1.14 mol O2/g/min, with p < 0.001. This abnormal metabolism could be due to uncoupled mitochondria, and may point to neurodegeneration.

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