Differences in visual fMRI activation and OCT metrics between affected and unaffected eyes after recovery from optic neuritis

Our focus was to investigate use of fMRI in the recovery process in multiple sclerosis patients with optic neuritis (ON). Recovery from ON is variable with most patients making good recovery but some noticing residual deficits. We stimulated each eye with varying contrast visual and a flashing quadrant paradigms. We observed significant correlations in the affected eye between macular volume and low contrast stimuli (2.5%: p<0.049, 1.25%:p<0.003), and average quadrant (p<0.020) volumes, and between retinal nerve fiber layer thickness and lowest contrast stimuli (1.25%:p<0.024), and average quadrant volume (p<0.003). No correlations were observed in the unaffected eye.

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