Meeting Banner
Abstract #4340

Local tissue volume changes in early MS are most strongly reflected in non-peripheral grey matter

Courtney A Bishop 1,2 , Jean SZ Lee 3 , Charlotte L Thomas 4 , Rebecca Quest 5 , Lesley Honeyfield 5 , Paolo A Muraro 2,6 , Adam D Waldman 2,5 , and Rexford D Newbould 1,7

1 Image Analysis Department, Imanova Centre for Imaging Sciences, London, United Kingdom, 2 Division of Brain Sciences, Imperial College London, London, United Kingdom, 3 Radiology Department, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 4 Department of Medicine, St George's Hospital, London, United Kingdom, 5 Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 6 Department of Clinical Neurosciences, Imperial College Healthcare NHS Trust, London, United Kingdom, 7 Division of Experimental Medicine, Imperial College London, London, United Kingdom

Volumetric T1 and T2-weighted volumes were acquired on 38 MS patients with average disease duration of 2 years, but grouped into two age brackets, and 52 age-group matched controls. Manually delineated white matter (WM) and grey matter (GM) lesions were lesion-filled in the automated segmentation of GM and WM with Sienax and FIRST. WM volumes were not significantly different between early MS subjects and controls, however, GM and especially non-peripheral GM volumes were, such as in the thalamus and putamen (P<0.001 in each). The younger MS group had significantly reduced volume in the caudate and the hippocampus (P<0.001 for both), which was not reflected in the older group.

This abstract and the presentation materials are available to members only; a login is required.

Join Here