Abstract #4340
Local tissue volume changes in early MS are most strongly reflected in non-peripheral grey matter
Courtney A Bishop 1,2 , Jean SZ Lee 3 , Charlotte L Thomas 4 , Rebecca Quest 5 , Lesley Honeyfield 5 , Paolo A Muraro 2,6 , Adam D Waldman 2,5 , and Rexford D Newbould 1,7
1
Image Analysis Department, Imanova Centre
for Imaging Sciences, London, United Kingdom,
2
Division
of Brain Sciences, Imperial College London, London,
United Kingdom,
3
Radiology
Department, Oxford University Hospitals NHS Trust,
Oxford, United Kingdom,
4
Department
of Medicine, St George's Hospital, London, United
Kingdom,
5
Department
of Imaging, Imperial College Healthcare NHS Trust,
London, United Kingdom,
6
Department
of Clinical Neurosciences, Imperial College Healthcare
NHS Trust, London, United Kingdom,
7
Division
of Experimental Medicine, Imperial College London,
London, United Kingdom
Volumetric T1 and T2-weighted volumes were acquired on
38 MS patients with average disease duration of 2 years,
but grouped into two age brackets, and 52 age-group
matched controls. Manually delineated white matter (WM)
and grey matter (GM) lesions were lesion-filled in the
automated segmentation of GM and WM with Sienax and
FIRST. WM volumes were not significantly different
between early MS subjects and controls, however, GM and
especially non-peripheral GM volumes were, such as in
the thalamus and putamen (P<0.001 in each). The younger
MS group had significantly reduced volume in the caudate
and the hippocampus (P<0.001 for both), which was not
reflected in the older group.
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