Abstract #4341
Phase contrast MRI differentiates between brain lesions in Neuromyelitis optica and Multiple sclerosis preliminary data from a 7T MRI study
Tim Sinnecker 1 , Sophie Hahndorf 1 , Katharina Mueller 1 , Petr Dusek 2,3 , Lutz Harms 4,5 , Sanjeev Chawla 6 , Thoralf Niendorf 7,8 , Ilya Kister 9 , Friedemann Paul 1,4 , Yulin Ge 6 , and Jens Wuerfel 1,2
1
NeuroCure Clinical Research Center, Charit-
Universitaetsmedizin, Berlin, Berlin, Germany,
2
Institute
of Neuroradiology, Universitaetsmedizin Goettingen,
Niedersachsen, Germany,
3
1st
Faculty of Medicine and General University Hospital in
Prague, Department of Neurology and Center of Clinical
Neuroscience, Charles University in Prague, Praha, Czech
Republic,
4
Experimental
and Clinical Multiple Sclerosis Research Center, Charit
Universitaetsmedizin Berlin, Berlin, Germany,
5
Department
of Neurology, Charit - Universitaetsmedizin Berlin,
Berlin, Germany,
6
Department
of Radiology, NYU School of Medicine, New York, NY,
United States,
7
Berlin
Ultrahigh Field Facility, Max Delbrueck Center for
Molecular Medicine, Berlin, Germany,
8
Max
Delbrueck Center for Molecular Medicine, Experimental
and Clinical Research Center, Charit -
Universitaetsmedizin Berlin, Berlin, Germany,
9
Multiple
Sclerosis Care Center, Department of Neurology, NYU
School of Medicine, New York, NY, United States
Differentiating between seronegative Neuromyelitis
optica (NMO) and multiple sclerosis (MS) with e.g.
spinal predominance has remained challenging in clinical
routine. Small supratentorial white matter lesions
suggestive for MS may also be observed on conventional
MRI in NMO. Here we studied the potential of highly
resolving phase contrast MRI at 7 Tesla (T) that
provides additional information on the tissue
microstructure in differentiating NMO lesions from MS
plaques. We observed unique morphological features of
NMO and MS plaques. Hence, phase contrast MRI can be
used to improve the distinction between NMO and MS brain
lesions.
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