Abstract #4342
High Percentage of MS lesions found to have a central vein using single slice SWI at 7 Tesla
Jacob Alois Matusinec 1 , Zahra Hosseini 2 , Junmin Liu 3 , David A Rudko 4 , Matthew P Quinn 3 , Marcelo kremenchutzky 5 , Ravi Menon 3,6 , and Maria Drangova 3,7
1
Medicine, Schulich School of Medicine &
Dentistry, Western University, London, Ontario, Canada,
2
Biomedical
Engineering Graduate Program, Western University,
Ontario, Canada,
3
Imaging
Research Laboratories, Robarts Research Institute,
Western University, London, Ontario, Canada,
4
Brain
Imaging Centre Montreal Neurological Hospital and
Institute, McGill University, Quebec, Canada,
5
Department
of Clinical Neurological Sciences, Schulich School of
Medicine & Dentistry, Western University, London,
Ontario, Canada,
6
Centre
for Functional and Metabolic Mapping, Robarts Research
Institute, Western University, London, Ontario, Canada,
7
Department
of Medical Biophysics Schulich School of Medicine &
Dentistry, Western University, Ontario, Canada
MS lesions tend to be associated with a central vein.
Recent advances in MRI technology may allow researchers
and clinicians to view these venocentric lesions to
accurately diagnose MS. In this study we localized
lesions using FLAIR images, then used a novel 7T SWI
technique (IEV-SWI) to obtain high-quality venograms and
calculate the percent of lesions with a central vein
(%LCV). We found a very high average %LCV from three
observers (94.6 5.1%, 97.4 4.0%, and 86.4 3.8%) in
five MS patients suggesting IEV-SWI may be a useful
method for detecting small veins in MS lesions.
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