Abstract #4343
Diagnose acute gadolinium enhancing multiple sclerosis lesions using gradient echo MRI (R2* and QSM) without gadolinium injection
Lijie Tu 1,2 , Yan Zhang 1,3 , Ajay Gupta 1 , Joseph Comunale 1 , Thanh Nguyen 1 , Susan Gauthier 4 , and Yi Wang 1,5
1
Radiology, Weill Cornell Medical College,
New York, NY, United States,
2
Applied
& Engineering Physics, Cornell University, Ithaca, NY,
United States,
3
Radiology,
Tongji Hospital, Tongji Medical College, Huazhong
University of Science & Technoology, Wuhan, Hubei,
China,
4
Neurology,
Weill Cornell Medical College, New York, NY, United
States,
5
Biomedical
Engineering, Cornell University, Ithaca, NY, United
States
During an multiple sclerosis (MS) lesion formation,
first there is acute blood-brain-barrier breakdown
(gadolilnium (Gd) enhancing) and demyelination, reducing
subvoxel structure heterogeneity or R2*. Then there is
subacute clearance of myelin debris by
microglia/macrophages (m/M) and further inflammation by
m/M laden with iron, increasing susceptibility as
measured on QSM. We found most Gd-enhancing lesions are
R2* hypointense and QSM isointense. Without using Gd
injection, the sensitivity to identify Gd-enhancing
lesions as isointense on QSM, is 89%, and the
specificity is 97%.
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